CCL22 and atopic eczema: Moreover, a study on atopic dermatitis found that UPF significantly inhibited the mRNA expression of several key chemokines, including thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC), and RANTES (also known as CCL5), in TNF-α or IFN-γ-induced human epidermal keratinocytes [46].