Topical fucoidan (Cladosiphon okamuranus, 49.8 kDa) has also demonstrated anti-inflammatory activity in the skin, as seen in atopic dermatitis and wound models, including reductions in mast cells, epidermal thickness, and serum IgE in mice, as well as broader dermatologic benefits in human cosmetic testing [117,118,119]. Here, IGHE is linked to atopic eczema.