FLT3-mutated AML cells display a unique metabolic profile characterized by low levels of pyruvate dehydrogenase kinase 1 (PDK1), which is involved in deactivating pyruvate dehydrogenase (PDH), a critical mitochondrial multienzyme complex responsible for catalyzing the oxidative decarboxylation of pyruvate, with this expression pattern correlating with heightened OXPHOS states. The gene discussed is PDK1; the disease is acute myeloid leukemia.