In parallel, perturbation of guanine nucleotide biosynthesis, either through suppression of guanosine or pharmacological inhibition of Inosine Monophosphate Dehydrogenase 2 (IMPDH2), has been shown to induce myeloid differentiation and impair the oncogenic Lens Epithelium Derived Growth Factor (LEDGF)/menin/MLL-fusion complex in AML and MLL-rearranged leukemias. Here, MEN1 is linked to acute myeloid leukemia.