Specifically, JNK, activated by ROS and endoplasmic reticulum stress (e.g., via IRE1α), is required for survival of FLT3-ITD leukemia cells, and its pharmacologic inhibition using SP600125 induces apoptosis even in TKI-resistant FLT3-ITD-TKD blasts [121]. This evidence concerns the gene FLT3 and leukemia.