Results: CCDC26 rs891835 G/T, G/G, and G/T-G/G genotypes were analyzed and determined to increase glioblastoma risk (G/T OR = 1.96, 95% CI: 1.38–2.77, p = 0.0002, I2 = 0%; G/G OR = 1.33, 95% CI: 0.46–3.85, p = 0.60, I2 = 0%; G/T − G/G OR = 1.96, 95% CI: 1.39–2.76, p = 0.0001, I2 = 0%). Here, CCDC26 is linked to glioblastoma.