PDCD6IP and neoplasm: Several accessory components further regulate the ESCRT-dependent pathway, including VPS4 (Vacuolar Protein Sorting-associated Protein 4), an ATPase that powers the recycling of ESCRT-III [131], ALIX (Apoptosis-Linked Gene 2-Interacting Protein X) that recruits ESCRT-III proteins to the cell membrane [132], Syntenin that works with ALIX to recruit specific cargo [102], Ndfip1 (Nedd4 Family-Interacting Protein 1) that recruits ubiquitin ligases to promote cargo recognition [133], and TSG101 (Tumor Susceptibility Gene 101) that engages ubiquinated cargo for ESCRT-I [134].