Since thick, rigid MWCNTs such as MWCNT-7 are cytotoxic to mesothelial cells [15,16,23], and since damaged mesothelial cells release HMGB1, and HMBG1 is involved in the development of mesothelioma [12,13,14,24,25], the mechanism of MWCNT-7 induction of mesothelioma is relevant to humans. The gene discussed is HMGB1; the disease is mesothelioma.