However, CA appears to suppress the expression of several of these genes, including CKS1B, CCNA2, and CCND1, while simultaneously promoting the upregulation of tumor-suppressor genes, such as peroxiredoxin 1 (PRDX1) and cyclin-dependent kinase inhibitor 1 (CDKN1A, also known as P21). This evidence concerns the gene CDKN1A and neoplasm.