Serum or plasma profiling consistently shows that levels of triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) are generally lower in lean MASLD patients than in those with obesity-associated MASLD, yet remain elevated when compared to lean or obese individuals without liver disease [7]. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.