FGF21 and type 2 diabetes mellitus: Specific miRNAs, such as miR-193a-5p, have been linked to altered glucose metabolism and increased risk of T2DM in large population studies, while miR-99b appears to influence lipid handling by regulating hepatic FGF21, with potential local analogs in skeletal muscle and adipose cross-communication [253,254,255,256,257].