In obesity and T2DM, CD36 becomes constitutively localized at the membrane through S-acylation by zinc finger DHHC-type palmitoyltransferase 4 (zDHHC4), which is upregulated by forkhead box protein O1 (FoxO1) signaling [98]. The gene discussed is ZDHHC4; the disease is obesity due to melanocortin 4 receptor deficiency.