Wei et al. [18] demonstrated that propionate induces ferroptosis in AML cells through two coordinated mechanisms: (1) Additionally, propionate can induce iron depletion through the mediation of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4); and (2) propionate could promote the accumulation of reactive oxygen species (ROS) and disrupt redox balance, leading to mitochondrial fission and mitophagy, thereby enhancing ferroptosis and apoptosis in AML cells. Here, ACSL4 is linked to acute myeloid leukemia.