Ang-2 and related Tie2 axis markers associate with retinopathy and mortality, but effect sizes are modest in many cohorts (e.g., in Ugandan children, ANG-1 distinguished CM from UM with ~70% sensitivity and 75% specificity; AUCs for single markers often ≤0.71) [6,13,24]. The gene discussed is ANGPT2; the disease is retinal disorder.