For example, transcriptomic profiling of brain endothelium exposed to Plasmodium-infected erythrocytes identified specific markers: the metalloprotease ADAMTS18 emerged as the top discriminator between uncomplicated and severe malaria, and two others (angiopoietin-like 4 and Inhibin-βE) could distinguish cerebral malaria cases among severe infections [31]. The gene discussed is ADAMTS18; the disease is infection.