KDR and neoplasm: Hypoxia serves as a major driver of numerous cancer-related processes, including enhanced aerobic glucose metabolism [295,296], activation of angiogenesis via factors like VEGF and vascular endothelial growth factor receptor (VEGFR) [297,298], the initiation of EMT pathways [299,300,301], and the engagement of immune cells that support tumor growth such as myeloid cells [302], regulatory T cells [303], and tumor-associated macrophages [304].