For instance, a combination of N-acetylcysteine (NAC) and curcumin significantly reduced oxidative damage and neuroinflammation in models of Alzheimer’s disease by lowering neuronal apoptosis, lipid peroxidation, and pro-inflammatory cytokines such as TNF-α and IL-1β [133]. The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.