The results of the meta-analysis show that the administration of Lactated Ringer is significantly associated with a lower probability of admission to the intensive care unit (RR: 0.39; 95% CI: 0.18–0.85; p = 0.02), a reduction in the risk of progression of acute pancreatitis to more severe forms (RR: 0.63; 95% CI: 0.40–0.98; p = 0.04), and significantly lower levels of C-reactive protein at 48 h (SMD: −3.91; 95% CI: −4.66 to −3.17; p < 0.00001), which suggests a possible early anti-inflammatory effect. The gene discussed is CRP; the disease is acute pancreatitis.