MMP-8 is one of the main MMPs responsible for the irreversible destruction of periodontal tissues [11], and its high levels in gingival crevicular fluid correlate with the severity of periodontitis [23], accompanied by symptoms such as loss of attachment [17,24], periodontal pocket depth, and bleeding on probing, as well as high plaque index [17]. Here, MMP8 is linked to periodontitis.