PTGS2 and alcoholic fatty liver disease: Furthermore, alcohol consumption activates pro-inflammatory cytokines and signaling cascades—such as nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS)—that contribute to both neurocognitive symptoms and alcoholic fatty liver disease (AFLD) [1,8,11].