Fontan patients without CHF had NT-proBNP levels similar to healthy children [25], and the plasmatic level of NT-proBNP seems also related to the type of Fontan circulation: older types (i.e., atrio-pulmonary connection or atrio-ventricular connection) that involve more atrial tissue in the systemic venous pathway have shown higher NT-proBNP levels independently of their cardiac status compared to patients with TCPC. The gene discussed is NPPB; the disease is congestive heart failure.