The subsequent immunological activation in MIS-C shows features of autoimmunity or dysregulated immune response as demonstrated by the presence of autoantibodies targeting cardiac tissue, the gastrointestinal tract, endothelial and immune cells, and hyperinflammation as demonstrated by markedly elevated concentrations of a broad spectrum of serum cytokines, including IL-1β, IL-6, IL-8, IL-10, IL-17, IL-18, IFN-γ, and TNF, leading to elevated inflammatory markers and multi-organ dysfunction [59,73,74,75,76]. This evidence concerns the gene TNF and Autoimmunity.