BAK1 and neoplasm: Chemotherapeutic drugs such as paclitaxel, vincristine, vinblastine, etoposide, doxorubicin and camptothecin have demonstrated significant apoptosis induction in cancer cells through up-regulation of Bax and Bak and the induction of caspase activation, inhibition of angiogenesis, eradication of established tumours and enhancement of survival in mice [33].