Once carcinoma has disseminated throughout the peritoneal cavity, IL-8 binds to CXCR1 on tumor cells triggering the signaling cascade and amplifying aggressive tumor growth, metastasis, and fibrosis [46,47,48,75,76], ultimately leading to tumor growth, disease progression, peritoneal spread in PC. Here, CXCL8 is linked to pachyonychia congenita.