As IL-8 levels are elevated in the secretome of peritoneal fluid in the setting of PC [1], activated neutrophils are continuously stimulated within the peritoneal cavity to release various proinflammatory cytokines, proteases, and ROS, remodeling the extracellular matrix, promoting angiogenesis, and amplifying a pro-tumorigenic microenvironment that supports tumor growth and further dissemination in PC [77]. This evidence concerns the gene CXCL8 and pachyonychia congenita.