Cancer cells can be classified as “immune hot” (high infiltration of CD8+ and CD3+ T cells in colon cancer tissues), “immune cold” (low immune cell infiltration), both of which were closely associated with survival rates [21], and “immune altered” (excluded) [T cells present in the tumour periphery cannot enter the tumour, an effect strongly related to VEGF expression [22]]. Here, VEGFA is linked to neoplasm.