ERBB2 and neoplasm: However, tumor characteristics in older adults sometimes have a “paradoxical” feature and a retrospective analysis performed on 3947 women, reclassified according to intrinsic molecular subgroups with gene expression microarray dataset (PAM50), showed that luminal B-like tumors were twice as common among patients > 70 years of age if compared to women in the pre-menopausal group (<50 years of age) (32% vs. 15%), while in the same age groups the combined incidence of HER2+ or TN tumors were 14% and 38%, respectively [47].