As shown in Figure 6H, we found that, compared with the WT-LSDV, infection by the LSDVΔORF137-EGFP strain showed no significant effect on IRF3 expression but had higher phosphorylation of IRF3 at 6 h after virus infection, which corresponds to lower virus replication at 6 h; however, with the increase in time, the difference in IRF3 phosphorylation on virus replication was not obvious, indicating enhanced activation of interferon signaling during the early stage of virus infection. Here, IRF3 is linked to viral infectious disease.