ISL2 and Cognitive impairment: An IPA network analysis for MBr also showed an association between METH dependance, amphetamine delusional disorder, addictive behaviors, long-term synaptic depression, and cognitive impairment and the identified DEGs in the three pairwise comparisons, namely SR vs. CT (Gal, Cartpt, Akt, Erk, Hdc, Isl1, Isl2, and dopamine receptors were up-regulated, and Tbr1 and Npas4 were down-regulated), SS vs. CT (Calml3 and Znf648 were up-regulated, while Fbn2, Zfyve26, Lyst, Cep85l, and Ankrd11 were down-regulated), and SR vs. SS (Col4a3, Slc6a2, Atp7a, and Itga8 were up-regulated) (Figure 5H–J).