IL18 and systemic lupus erythematosus: The P2X7 receptor is involved in systemic lupus erythematosus through the activation of the NLRP3 inflammasome and increased production of IL-1β and IL-18 by lupus patient-derived macrophages [84,85], thereby contributing to the cardiovascular, cutaneous, and renal manifestations of lupus [86,87,88].