While Ogg1 mRNA expression was not modified, we observed a downregulation of Gpx2 and Nqo1 mRNA expression in thyroid tumors from 2- and 8-month-old RET/PTC3 Dicer1(+/+) mice compared to WT thyroids, suggesting that redox homeostasis is unbalanced in RET/PTC3 tumors. The gene discussed is OGG1; the disease is thyroid tumor.