They also align with earlier studies by Zhang et al., who reported that complete inactivation of Dicer1 resulted in smaller tumors in a prostate cancer mouse model, with increased number of TUNEL-positive cells following Dicer1 total loss [39] or Arrate et al., who found that Dicer1 total loss was strongly disfavored during B cell lymphoma development [40]. Here, DICER1 is linked to Familial prostate cancer.