First, deletion of XPO1 in the DEK-NUP214 positive FKH-1 AML cell line as well as selective XPO1 inhibition by eltanexor in primary human AML cells reduced the XPO1 expression, disrupted XPO1 chromatin co-localization with the fusion protein, and induced apoptosis and cell cycle arrest. This evidence concerns the gene NUP214 and acute myeloid leukemia.