The DEK-NUP214 and SET-NUP214 fusion proteins show several similarities (Table 4, see Section 6 and Section 7 for details) both with regard to the NUP214 fusion partners, the NUP214 contribution to the fusion molecules and possibly also the chemosensitivity of immature leukemic cells (i.e., AML and ALL) with these translocations. The gene discussed is SET; the disease is acute lymphoblastic leukemia.