KMT2A and acute myeloid leukemia: Finally, HOX gene expression is also regulated by other mechanisms than CDX molecules, including Glycogen synthetase kinase 3 (GSK3)/CREB/MEIS1 [44] and Disruptor of telomeric-silencing 1-like (DOTIL) that catalyzes histone methylation and seems important for maintenance of HOXA gene expression in MLL-mutated/translocated AML [45].