Similarly, a significant decrease in Brn3a-positive cells was measured in the retinas of diabetic rats after 1 week of hyperglycemia [22], and the number of Brn3a-immunoreactive cell bodies was 20% fewer in 9-month-old Ins2Akita mice compared to wild-type controls [23]. The gene discussed is POU4F1; the disease is Hyperglycemia.