GNAI1 and post-traumatic stress disorder: Moreover, with designer receptors exclusively activated by designer drugs, the astroglial Gi-pathway was activated, which was subsequently used to explore the astrocytic function during enhanced fear learning while Specifically, astrocytes were functionally involved in mediating heroin withdrawal fear learning as significantly elevated colocalization of astrocytic membranes with neuronal post-synaptic density protein 95 was observed, indicating the neuroinflammatory role of astrocytes in post-traumatic stress disorder (PTSD) [139].