F2RL1 and colorectal carcinoma: To investigate the regulatory effect of curcumin on PAR-2 expression under inflammatory conditions, we examined both protein and mRNA levels in HT 29 and Caco-2 CRC cell lines following treatment with 50 μM and 100 μM curcumin, after LPS-induced stimulation (10 μg/mL), as justified in the Section 1 and Section Real-Time PCR for Quantification (qPCR).