Analysis of large cancer datasets reveals that F2RL1 expression is among the highest in colon adenocarcinoma compared to numerous other cancer types [57], and significantly higher than other PAR family members (F2R/PAR1, F2RL2/PAR3, F2RL3/PAR4) within CRC tissues [58]. Here, F2RL3 is linked to colon adenocarcinoma.