For instance, it has been recently observed that the siRNAs-mediated depletion of multiple HSPs (HSP27, HSP60, HSP70, or HSP90), made glioma cells more sensitive to apoptosis upon resveratrol treatment and decreased cell proliferation and colony-forming ability, by enhancing ROS generation, and inducing ER stress and UPR signaling [21]. Here, HSP90AB1 is linked to central nervous system cancer.