LMP744 (NSC 706744) an inhibitor of topoisomerase 1 damages DNA. This causes cell death. Researchers want to see if it can treat certain kinds of cancer. Exploratory Objective: Evaluate the effect of LMP744 on markers of DNA damage (yH2AX, pNbs1, pATR, ERCC1, RAD51, Topo1cc, Top1, SLFN11) and EMT in circulating tumor cells and pre- and post-treatment tumor biopsies in patients in the expansion cohort. This evidence concerns the gene TOP1 and cancer.