Knockdown of c-MYC following the addition of Doxycycline (Dox) to the murine Burkitt lymphoma cell line, P493-6, in vitro also led to a significant (p < 0.05) decrease in c-MYC and PA2G4 protein expression over 96 h (Figure 2C). This evidence concerns the gene PA2G4 and Burkitt lymphoma.