Hemizygous Th-MYCN+/− mice had a survival probability of 30% when the PA2G4 gene was wildtype, whereas both hemizygous PA2G4WT/DelEx1–5 and homozygous PA2G4DelEx1-/DelEx1–5 knockout equally increased tumor-free survival probability of the homozygous Th-MYCN+/+ mice to 80% (Figure 1C). Here, PA2G4 is linked to neoplasm.