The additional observation of altered gene expression in Alzheimer’s disease-related genes (APP, BACE2, SOD1) and oxidative stress markers (CAT, PTGS1) in DS hid-Neurons and hid-Astrocytes extends recent hypotheses linking early THs dysregulation with pathways relevant to DS-associated neurodegeneration [24]. The gene discussed is BACE2; the disease is early-onset autosomal dominant Alzheimer disease.