ACE and Friedreich ataxia: Kelly et al. [44], in a study involving 79 FRDA patients and 170 controls, showed an association between the rs5186 single-nucleotide polymorphism (SNP) in the angiotensin-II type-1 receptor (AGTR1) gene and FRDA, with this SNP also being related to an increase in interventricular septal wall thickness and left ventricular mass (LVM), while other SNPs in the same gene and in angiotensin-converting enzyme (ACE) and ACE2 genes showed a lack of association with FRDA.