FXN and Friedreich ataxia: In a metabolomic and lipidomic analysis of fibroblasts from nine FRDA patients and nine age- and sex-matched HC by Wang et al. [86], the main findings were an increase in 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) and β-hydroxybutyrate-CoA levels, increased levels of several ceramides (especially long-chain fatty acid ceramides related to oxidative stress; these were correlated with the GAA repeat length and the frataxin protein levels), and increased levels of PUFA-containing triglycerides and phosphatidylglycerols.