SELENOW and Friedreich ataxia: McMackin et al. [24], in a study on lymphocytes and skin fibroblasts from FRDA patients and histological dorsal rood ganglion from a mouse model of FRDA, described overlapping gene expression changes primarily affecting antioxidant genes related to selenium metabolism and GPx activity (selenoprotein W1-SEPW1-, GPX7, and TXNRD1), ten genes related to the positive regulation of the apoptotic process, and nine genes related to mitochondrial translation and transcription.