HMOX1 and Friedreich ataxia: The same group, in a study performed on skin fibroblasts from three FRDA patients compared to three HC using RT-qPCR and Western blotting, showed a significant decrease in mRNA expression and protein levels of NRF2, NAD(P)H quinone oxidoreductase 1 (NQO1), Heme Oxygenase-1 (HO-1), and GCL in FRDA patients [23].