MT-ND2 and Friedreich ataxia: Singh et al. [45], in a PCR amplification and sequencing analysis of the D-loop, NADH (nicotin–adenin–dinucleotide) dehydrogenase subunits 1-6 (ND1-6), and ATP regions of the mitochondrial genome (comprising 50% of the latter) involving 30 FRDA patients and 62 controls, showed a significantly higher load of mitochondrial variations per individual, and an over-representation of the non-synonymous variation p.L237M in ND2 in FRDA cases compared to controls, this variation being associated with longevity and myocardial infarction.