Indelicato et al. [83], in a proteomic analysis in skeletal muscle of five FRDA patients and four age-matched HC, identified 228 DEPs (227 downregulated), with most of them related to oxidative phosphorylation, ribosomal elements, mitochondrial architecture control, and fission–fusion pathways and 74% of them being targeted to NRF2. This evidence concerns the gene NFE2L2 and Friedreich ataxia.