For instance, Liu et al. synthesized an FR/NIR fluorescent CP, designated PFDBT-POSS, consisting of a poly [9,9-di(hexyl)fluorene]-alt-co-[4,7-bis(thiophen-2-yl)-2,1,3-benzothiazole] (PFDBT) backbone with bulky polyhedral oligomeric silsesquioxane (POSS) side chains, and subsequently employed it to construct a fluorescent sensor for the accurate diagnosis and imaging of targeted cancer cells through click reaction with an anti-HER2 affibody [184]. Here, ERBB2 is linked to cancer.