Moreover, it has been shown that FOXO 1 can not only target tumor cells, but also inhibit the progression of HCC by inducing and recruiting macrophages to antitumor differentiation, while inhibiting the expression of CD206, IL‐10, Arg‐1(Arginase 1, Arg‐1), and IL‐6 mRNA in macrophages [119]. This evidence concerns the gene ARG1 and neoplasm.