In this study, we examined the relationship between TRNT1 and TIME and found a negative correlation between TRNT1 expression and immune cells, such as monocytes, mast cells, effector memory CD8+ T cells, and activated B cells In early breast cancer, M1‐type Tumour‐Associated Macrophages, derived from monocytes, activate anti‐tumour immunity and promote tumour cell clearance through the release of factors like IL‐6, IL‐12, and TNF‐α; reduced monocyte infiltration weakens this anti‐tumour immune surveillance [33]. The gene discussed is TRNT1; the disease is breast cancer.