BLOC1S1 and Insulin resistance: Mitochondrial dysfunction and oxidative stress are inextricably linked to the development of insulin resistance.[29] We have previously shown that GCN5L1 deletion has no obvious effect on liver mitochondrial respiration.[25] Similar mitochondrial respiration and comparable glycolysis rate were confirmed in primary hepatocytes from GCN5L1 LKO and Con mice (Figure S1a,b, Supporting Information).