[48] Interestingly, UPRMT induced by mitochondrial protease CLPP or LONP1 deletion protects mice from diet‐induced insulin resistance.[17, 18] It's not clear whether acetylation regulates the chaperone function of GRP75 in the context of UPRMT and whether this process participates in the regulation of insulin sensitivity. This evidence concerns the gene LONP1 and Insulin resistance.