Dysregulation of mitochondrial protein acetylation, for instance in Sirt3 knockout, induces hepatic lipid disorder.[37] Lipid accumulation is the major risk factor for hepatic insulin resistance, underlying the mechanism of increased inflammation, the diacylglycerols (DAG) destroyed pathway decay, and ER stress.[38] However, whether acetyl‐modification is directly involved in the development of insulin resistance remains unresolved. The gene discussed is SIRT3; the disease is Insulin resistance.