An analysis of adults with T2DM or prediabetes, without HF at baseline, in four cohort studies (Atherosclerosis Risk in Communities[ARIC], Cardiovascular Health Study[CHS], Framingham Offspring Study[FHS], and Multi-Ethnic Study of Atherosclerosis[MESA])showed that NT-proBNP alone was more effective in predicting HF in subjects with low/intermediate WATCH-DM scores (<13) than in those with high WATCH-DM scores (≥13) (C-index 0.71 [95% CI 0.68–0.74] vs. 0.64 [95% CI 0.61–0.66]). The gene discussed is NPPB; the disease is diabetes mellitus.