Third, elevated clinical risk or abnormal levels of cardiac biomarkers (e.g., BNP ≥50 pg/mL, NT-proBNP ≥125 pg/mL, or hs-cTn ≥99th percentile), in combination with echocardiogram evaluation, further subdivides stage B HF (B1-B4). Here, NPPB is linked to hydrops fetalis.