The genes representing the probes, CpG sites and SNPs in Figure 3A - namely, AGPAT1, ATP6V1C1, BUB1B, CARD11, C19orf62, PNPLA2, RCHY1 and RNF5 - have not been extensively studied in the context of cognitive decline. The gene discussed is BUB1B; the disease is Mental deterioration.