Functionally, ANGPT1 plays a critical role in maintaining blood-brain barrier (BBB) integrity and vascular stabilization, and its dysregulation has been implicated in BBB breakdown and increased neurovascular permeability observed in MS lesions66, We also found that it interacts with the MS treatment drug corticotropin, which suggests that ANGPT1 may serve as a potential therapeutic mediator or downstream effector in modulating vascular responses during immunomodulatory treatment in MS. Here, POMC is linked to myeloid sarcoma.