On the other hand, for example, Myozenin-2 (Myoz2), Troponin T cardiac muscle (Tnnt2), Troponin I cardiac muscle (Tnni3), Myosin light chain 1/3 skeletal muscle isoforms (Myl; Myl3) and Actin, gamma-enteric smooth (Actc1/Actg2) proteins were upregulated in healthy myocardium but downregulated in MI tissue (Fig. 6). The gene discussed is TNNI3; the disease is myocardial infarction.