Traumatic injuries typically carry greater risk of post-operative complications due to the nature of their provenance – they are acute, unplanned emergencies that are frequently contaminated by the environment from which they resulted (e.g., dirt, debris, bacteria).24 However, in our cohort, injury-associated damage carried lower odds of several complications including ESR/CRP elevation, wound dehiscence, and post-operative infection. This evidence concerns the gene ESR1 and infection.