Immunodeficient patients treated with silicone-based biomaterials had higher odds of developing local tissue edema (OR= 1.857, 95%CI, 1.123–3.069), ESR/CRP elevation (OR= 6.163, 95%CI, 2.545–14.929), post-operative bleeding (OR= 3.612, 95%CI, 1.639–7.691), seroma formation (OR= 6.163, 95% CI, 2.545–14.929) and cellulitis or lymphadenitis (OR= 1.662, 95% CI, 1.2–2.302). The gene discussed is CRP; the disease is cellulitis.