In univariable analysis, individuals with autoimmune and immunodeficiencies treated with ECM had higher odds of developing local tissue edema, sepsis, ESR/CRP elevation, wound dehiscence, post-operative infection, post-operative bleeding, tissue ischemia cellulitis/lymphadenitis, and overall graft complications compared to immunocompetent controls (Figure 2). The gene discussed is CRP; the disease is infection.