In fact, one of the four mutated genes constituting the RRS model, WDFY4, has been reported to be crucial for both antiviral and anti-tumor immune responses, which is highlighted by a study showing that the loss of WDFY4 gene results in the decreased number of CD8+ T cells through reactive oxygen species (ROS)-induced apoptosis (Theisen et al. 2018). Here, WDFY4 is linked to neoplasm.