In addition to TMB which calculates the overall number of mutations, individual gene mutations, especially those drive the development of cancer, e.g., KRAS proto-oncogene, GTPase (KRAS) (Jiang et al. 2018), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) (Chung et al. 2021), Lysine Methyltransferase 2B (KMT2B) (Li 2017), Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2) (Xiang et al. 2018) and Fibroblast Growth Factor Receptor (FGFR) (Yoshimoto et al. 2020), were also reported to be associated with poor prognosis of patients with CC. Here, PIK3CA is linked to cancer.