PAICS and infectious disease: The virulence genes analyzed based on the DFVF database included CaNik1, CHS2, DUR1,2, HSP90, ICL1, PMT1, PMT2, PMT4, SSD1, TPS2. The host pathogenic genes identified by comparison with the PHI-base database included CaCHS1, ADE2, FAS2, PMR1, CaTPS2, Tfp1. KEGG annotation showed enrichment in infectious disease pathways.