HLA-A*11(*1101), HLA-B*15(*1501), HLA-B*35(*3503) and HLA-B*52 are related to the susceptibility of HSP in Mongolian and Han populations, and HLA-B*40 and HLA-B*07 may have a protective effect on HSP (34). This evidence concerns the gene HLA-A and hereditary spastic paraplegia.