NR4A1 and colorectal carcinoma: Celastrol (Figure 2, 27) is a bioactive component extracted from Tripterygium wilfordii, and has shown may induce autophagy in CRC by targeting Nur77 which is a pro-cancer regulator and upregulating ATG7 (Zhang W. et al., 2022), which offers novel perspectives on celastrol’s antitumor potential in CRC.