Diels, has been identified as a ferroptosis inducer in CRC cell (Wen et al., 2025; Cao et al., 2024) found angelic acid destabilizes nuclear factor erythroid 2-related factor 2 (NRF2), a crucial regulator of oxidative stress responses, through protein degradation mechanisms, as evidenced including elevated malondialdehyde (MDA) levels, enhanced lipid peroxidation, and increased expression of CHAC1 and PTGS2 -effects that were reversed upon administration of the ferroptosis inhibitor Fer-1. This evidence concerns the gene NFE2L2 and colorectal carcinoma.