MUC5AC and colorectal carcinoma: Ginsenoside compound K (Figure 2, 3), a dammarane-type tetracyclic triterpene, is derived from Panax ginseng, demonstrating diverse therapeutic properties including hypoglycemic, anti-aging, anti-allergic, anti-inflammatory and CRC-suppressing activities (Shao et al., 2022; Shao et al., 2022) found that ginsenoside compound K exerts anti-CRC effects through gut microbiota modulation, specifically enhancing populations of Akkermansia species (mucin-degrading commensals) while suppressing pathogenic Rikenellaceae_RC9_gut_group populations in AOM/DSS-induced colitis models.