NFKB1 and colorectal carcinoma: The bacterial component LPS additionally stimulates Toll-like receptor 4 (TLR4) receptors, initiating MYD88-dependent NF-κB activation that elevates miRNA-21 levels while suppressing RASA1 expression and molecular cascade subsequently triggers RAS-MAPK signaling, leading to S-phase cell cycle arrest and consequent enhancement of malignant cell multiplication in CRC (Sulit et al., 2023).