After emodin treatment, ROS generation, lipid peroxidation levels, MDA levels, iron levels, and the expressions of NCOA4 and transferrin receptor (TFRC) increased in CRC, while GSH/GSSG ratio, System Xc-, GPX4 and ferritin heavy chain 1 (FTH1) expression decreased. This evidence concerns the gene GPX4 and colorectal carcinoma.