In a mouse model of allergic rhinitis, it exerts anti-allergic effects by suppressing the Th2 response, thereby reducing IgE and histamine levels, inhibiting the TLR4/MyD88/NF-κB pathway to attenuate inflammation, and promoting Th1 activation while restoring the Th1/Th2 immune balance (Li et al., 2023a; Chen et al., 2020a). The gene discussed is IGHE; the disease is allergic rhinitis.