NFE2L2 and myeloid sarcoma: Oxidative stress and mitochondrial dysfunction in MS (Kim et al., 2015) are partly attributed to the imbalance of the NRF2 signaling pathway, which regulates redox homeostasis and mitochondrial function and plays a crucial role in modulating neuroinflammation (Branca et al., 2017; Brandes and Gray, 2020; Chen et al., 2009; MichaliČKovÁ et al., 2020).