In addition, it is also reported that inflammatory reactions were significantly elevated in patients with ruptured aortic aneurysm (median CRP value: 2.4 (IQR 0.65-8.6) mg/dL, median WBC value: 13200 (IQR 10500-17000)/μL) and that the elevation of CRP, WBC, and fibrinogen may be an indicator of acute phase response (i.e., rupture) due to vascular tissue damage and inflammation in atherosclerotic disease [16]. The gene discussed is CRP; the disease is aortic aneurysm.